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A theoretical multi-target strategy might combine: NAD+ for ongoing metabolic support: sirtuin activation, DNA repair, mitochondrial maintenance, nutrient sensing recalibration Epitalon for periodic telomere maintenance: cyclic telomerase activation to preserve replicative capacity and delay senescence onset This combination would address at least seven hallmarks between the two interventions

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Ignoring other cofactors: Glutathione needs a variety of cofactors to work optimally

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doi: 10.1111/aos.13526