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Introduction# CagriSema (cagrilintide + semaglutide, Novo Nordisk) and tirzepatide (Eli Lilly) represent the pinnacle of next-generation obesity pharmacotherapy, both achieving approximately 20% weight loss through different dual-mechanism approaches

These changes attenuated inflammation and insulin resistance while promoting islet -cell function through gastrointestinal hormone secretion

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It is advisable not to exceed approximately 3 g (3,000 mg) per day without medical supervision, as higher intakes are associated with an increased risk of adverse effects

Staying hydrated and avoiding strenuous activity immediately afterward can help maximize your results

Successful compliance depends on concordance shared decision making so that a suitable management plan can be put in place