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Terwilliger, T
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When Wnt proteins bind to their cell-surface receptors (Frizzled and LRP5/6), the destruction complex is inhibited, allowing -catenin to accumulate and enter the nucleus, where it activates Wnt target gene expression through interaction with T-cell factor (TCF) transcription factors

This dimerization appears to induce a switch in intracellular signaling cascades in which administration of a dopamine agonist (quinpirole) alone leads to a rapid increase in Ca 2+ levels, an effect not observed in preparations expressing D2R in the absence of GHSR1a (Kern et al., 2012)

A microwave oven performed heat-induced epitope retrieval
