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Oral glutathione may produce modest, gradual brightening in some people by reducing oxidative stress and shifting melanin production, but genetics still set your baseline tone

doi: 10.3389/fphar.2022.864088 Received 28 January 2022 Accepted 14 March 2022 Published 12 April 2022 Volume 13 - 2022 Edited by Wiebke Kallenborn-Gerhardt, Goethe University Frankfurt, Germany Reviewed by Ana Isabel Arroba, Fundacin para la gestin de la investigacin Biomdica de Cdiz, Spain Pranav Kumar Prabhakar, Lovely Professional University, India Updates Copyright 2022 Busa, Kuthati, Huang and Wong

Zygotic DNA repair machinery (base excision repair) is activated at the expense of active demethylation of paternal DNA, another unexpected observation that links oxidative stress to errors in methylation [55,56]

On the other hand, it inhibits the expression of -secretase -site APP cleaving enzyme 1 (BACE1) and affects the activity of the -secretase complex, which is a component of presenilin-1 (PS1), limiting the formation of neurotoxic A1-42 [65,95,96,97,98]