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Healthy Weight Loss Maintenance with Exercise, GLP-1 Receptor Agonist, or Both Combined Followed by a Year without Treatment: A Post-Treatment Analysis of a Randomised Placebo-Controlled Trial

In expanded populations, comparing semaglutide versus sitagliptin for the composite outcome of myocardial infarction or stroke yielded a hazard ratio of 0.82 (95% confidence interval (CI) 0.74 to 0.91), and comparing tirzepatide versus dulaglutide for the composite outcome including mortality yielded a hazard ratio of 0.87 (95% CI 0.75 to 1.01)

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This is fundamentally different from severe caloric restriction, which strips both fat and muscle

With just mild gastrointestinal side effects, it was able to achieve a metabolically significant (more than 5%) weight reduction in 100% of the patients who received 8 mg and above [87]

Apps that track protein and fiber intake can help you maintain muscle mass even when eating feels difficult