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Indeed, with respect to diabetes, several mitochondrial diseases manifest with diabetic complications such as mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) and maternally inherited diabetes and deafness (MIDD)

The former seeks to decrease plasma levels of Lp(a) by causing apo(a) mRNA degradation, blocking apo(a) synthesis in the liver, and reducing Lp(a) secretion in particular [219], while the latter accomplishes the same goal by reducing Lp(a) levels through inhibiting the translation of the LPA gene's mRNA in hepatocytes and mutating the causing gene [232]

Cosby K, Partovi KS, Crawford JH, Patel RP, Reiter CD, Martyr S, Yang BK, Waclawiw MA, Zalos G, Xu X, Huang KT, Shields H, Kim-Shapiro DB, Schechter AN, Cannon RO 3rd, Gladwin MT

doi: 10.1186/1740-2557-2-5 517 MaesMMihaylovaILeunisJC