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Shared pathomechanisms of neuropsychiatric syndromes with fatigue as a leading symptom (PASC, PAIS, ME/CFS, IMD) Alterations of brain structure and connectivity PASC is currently being investigated by neuroimaging experts all over the world
ER stress activation can mitigate protein synthesis, induce ER chaperones to facilitate protein folding, and increase ER-associated degradation to reduce protein load
Patient phenotype critically defines the responsive subset
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Furthermore, acetyl-L-carnitine administration reduced MA-induced behavioral sensitization in an MA challenge performed after 7 days of MA administration at 2.5 mg/kg, followed by a 7-day withdrawal period in CD1 mice 46
[DOI] [PubMed] [Google Scholar] Jones JD, Comer SD, Kranzler HR (2015) The pharmacogenetics of alcohol use disorder
