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Description
Patients that maintained treatment response for 2 weeks at the end of the open label treatment period were eligible to be randomized to ongoing treatment with the same dose of VYVANSE (N=78) or switched to placebo (N=79) during the double-blind phase

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however, of the two options typically recommended (tretinoin 0.025% cream and adapalene 0.1% gel), I have a preference for adapelene 0.1% gel (sold as Differin in the United States), because adapalene 0.1% seems to be just as efficacious as tretinoin 0.025% while being much less irritating to patients (Dunlap et al
While a single deep injection is unlikely to cause serious harm, repeated intramuscular injections can lead to soreness and unpredictable medication levels, reducing weight-loss consistency

Cold chain storage requirements, syringe handling, injection site rotation, and the discomfort of subcutaneous administration all add friction to research protocols
