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Activation of AHR suppresses the development of EAE and patients with MS show lower levels of circulating AHR ligands compared to healthy controls, indicating an important role in MS pathology 283,284

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Unlike antigen purification from an inactivated pathogen, recombinant antigen synthesis allows for high expression levels and increases vaccination safety

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Pregnancy and lactation represent relative contraindications given absence of human safety data in these populations despite reassuring preclinical reproductive toxicology studies