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Retrieved 21 February 2021

10.1001/jamapsychiatry.2021.0638 JAMA Psychiatry

It was found that chronic lycopene could significantly reduce the levels of TBARS and total NO and increase the enzymatic activities of protein thiol, SOD, and CAT in the hippocampus and cortex of STZ rats, and also reduce the expression of serum inflammatory factors in STZ rats, thereby improving cognitive impairment (73)

In contrast, stressinduced Nrf2 targets are rather involved in antioxidant defense, xenobiotic detoxification, inflammation and immunity regulation, DNA repair, and prevention of apoptosis

You may think that the quick fix to a vitamin B12 deficiency is to eat foods that are rich in B12 or to take supplements, but the solution may not be that simple, as even meat eaters can be deficient in B12

Smaller increases occurred in the Northwest, South Central Coast, and the western Central Highlands