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However, under pathological conditions such as chronic infections, metabolic dysregulation, or age-related immune decline, senescent cells persist beyond their beneficial window

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(Figure) The optimal cutoff was a CT value of 110 ms (Youdens index: 0.83), at which, the RVV assay correctly identified active anticoagulation in 95.6% of cases with a sensitivity of 85.2% and specificity of 97.4%

This means that it tends to degrade when in contact with light