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However, more RCTs of vitamin B 12 supplementation and analysis of various markers (eg, total B 12 , holotranscobalamin, total Hcy and MMA, total folic acid, and if possible, polymorphism and/or methylation of genes) are needed to precisely identify the status of this micronutrient (before and after) in people with or without COVID-19 and thus facilitate the proper choice of vitamin B 12 form to be administered in treatment

& Murari, G

ITPPs action appears to be pH-dependent, showing greater activity in acidic, hypoxic environments, such as ischemic myocardium, while having minimal effect in well-oxygenated, alkaline tissues (Figure 2 for details)

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