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Moreover, maleimide-based conjugates suffer from thiol-exchange and retro-Michael instabilities 19,21

doi: 10.3389/fphar.2025.1599816 Received 25 March 2025 Accepted 16 June 2025 Published 22 July 2025 Volume 16 - 2025 Edited by Andrs Trostchansky, Universidad de la Repblica, Uruguay Reviewed by Satish Balasaheb Nimse, Hallym University, Republic of Korea Hctor Leonardo Montecino-Garrido, Center for Processed Food Studies, Chile Updates Copyright 2025 Tauchen, Huml, Jurek, Regenstein and Ozogul

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This is critical in oxidative TME conditions, particularly in the lung where exposure to environmental toxins exacerbates oxidative stress

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Underestimated health risks: polystyrene micro- and nano-plastics jointly induce intestinal barrier dysfunction by ROS-mediated epithelial cell apoptosis