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Due to the relatively constitutive activity and the membrane permeability of H 2 O 2 , NOX4-derived signals can integrate across subcellular compartments to modulate transcriptional responses for adapted metabolic homeostasis [32, 33]

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GIP is also implicated in nausea attenuation, which may be why GLP-1/GIP dual agonists like tirzepatide have a slightly better GI tolerability profile than pure GLP-1 agonists
This underscores the importance of collaborative efforts across various disciplines to bridge the gap between advancements in nanotechnology and their clinical applications
