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Factors such as hypoxia and nutrient limitation within the TME lead to the upregulation of GLUTs, particularly GLUT1 and GLUT3, to meet the energy demands of rapidly proliferating tumor cells

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Altered lymphocyte apoptosis in patients with SLE could contribute to an overload of nucleosome in circulation that could initiate an autoimmune response that might break tolerance, resulting in the autoimmune phenomena

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