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Institutional review board statement The animal experiment was approved by The Institutional Animal Care and Use Committee (IACUC) of Beijing Vital River Laboratory Animal Technology Co., Ltd., (No.PA23072602)

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Clinical studies have verified that combining these treatments leads to a denser collagen network and thicker epidermis than using either method in isolation, proving that the whole is greater than the sum of its parts

These phenomena can ultimately lead to a vicious cycle that promotes the development of inflammation and further damage to the barrier

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Hill, P