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Epigenetics and liver fibrosis

[DOI] [PubMed] [Google Scholar] 197.Chappell D.A., Fry G.L., Waknitz M.A., Muhonen L.E., Pladet M.W., Iverius P.H., Strickland D.K

Competing interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article

For example, complete loss of PGRN leads to Neuronal Ceroid Lipofuscinosis 67,68 , a neurodegenerative disease characterized by lysosomal accumulation of lipofuscin, a lipid-protein aggregate

In addition to mitochondrial ROS, glutaminolysis and the tricarboxylic cycle (TCA) affect the ferroptosis rate 33