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Recent studies have proven that autophagy can participate in ferroptosis and the main progress is called ferritinophagy (25), and the key interaction hub of these two pathways is NCOA4 and FTH1

The interaction between interleukin-22 and interleukin-17 inhibits keratinocyte differentiation while increasing their proliferation and motility, leading to nuclear retention within the stratum corneum, epidermal hyperplasia (acanthosis), and elongation of the epidermal rete ridges (papillomatosis) all of which are characterized by psoriatic skin plaques (Becher and Pantelyushin 2012)

-Mitochondrial Function

Facial pigmentation can result from sun exposure, acne, ageing, and hormonal changes

For the histological score, the epithelial tissue disorganization, crypt disorganization, immunocyte invasion, and erythrocyte invasion were quantified as show in Table 2

Chem Res Toxicol 24:16171629 Zhitkovich A, Song Y, Quievryn G, Voitkun V (2001) Non-oxidative mechanisms are responsible for the induction of mutagenesis by reduction of Cr(VI) with cysteine: role of ternary DNA adducts in Cr(III)-dependent mutagenesis