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For the uterine environment to be receptive to pregnancy, there must be activation, differentiation, and expansion of toleragenic dendritic cells (tDCs) and CD4 + CD25 + Treg cells (90, 91) Evidence from a CBAxDBA/2 mouse model of pregnancy failure suggests that components of seminal fluid prime the immunological landscape of the uterine environment for implantation (92)

It did take 2 weeks to heal and there was a small scab that formed but the results are amazing