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Recurrent sarcoidosis in lung transplant allografts: granulomas are of recipient origin

GBA1 mutations lead to reduced GCase activity, causing glucocerebroside to accumulate in lysosomes, thereby affecting lysosomal function, obstructing the autophagolysosomal pathway, and impairing the effective degradation of -syn aggregates [289]

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At 52 weeks, hyaline droplet and tubular degeneration were not found, but increased tubular pigmentation was observed

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10.1371/journal.pbio.2006203 37 FillebeenC.CharleboisE.WagnerJ.KatsarouA.MuiJ.ValiH.et al (2019)