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Notably, the spatiotemporal coordination among these signaling pathways likely determines the tissue specificity and functional outcomes of PGC-1 activation

Dietary interventions, such as increasing fiber, polyphenols, and probiotics, can modulate the gut microbiota to reduce TMAO production
Chemotherapy drugs : Ergothioneine, an antioxidant, could reduce the effectiveness of chemotherapy drugs that rely on oxidative stress to kill cancer cells

The underlying mechanisms include sympathetic overactivation, endothelial dysfunction, and increased myocardial oxygen demand [23]

[DOI] [PubMed] [Google Scholar] Evans W.J., Morley J.E., Argils J., Bales C., Baracos V., Guttridge D., Jatoi A., Kalantar-Zadeh K., Lochs H., Mantovani G., Marks D., Mitch W.E., Muscaritoli M., Najand A., Ponikowski P., Rossi Fanelli F., Schambelan M., Schols A., Schuster M., Thomas D., Wolfe R., Anker S.D

[DOI] [PubMed] [Google Scholar] 30.Cardiopulmonary effects of clenbuterol in the horse
