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Similarly, oral administration of either glutathione or other low-molecular-weight thiols (eg, 2-mercaptopropionylglycine or N-acetyl cysteine) to these patients neither substantially raises intracellular glutathione levels nor alters their acid-base balance or excretion of 5-oxoproline (71

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Disrupted endosomal traffic contributes to rheumatic diseases, including systemic lupus erythematosus, rheumatoid arthritis and systemic sclerosis, by impairing immune regulation and tissue homeostasis