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Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione

Canon, F., Maillard, M

We acknowledge support from the grants CNS2023-144443 and PID2023-151988OB-I00 funded by MCIN/AEI/ 10.13039/501100011033 and the European Union NextGenerationEU/PRTR and FEDER, EU

G.Castro-MuozL

Celastrol ( 26 , Figure 11 ) is a quinone methide triterpenoid isolated from Celastrus orbiculatus , and showed inhibitory effects against TNF--, IKK-, or MEKK1-mediated NF-B activation on the basis of NF-B luciferase activity [145]

While topical application of glutathione may not be as potent as injections or oral supplements, these products can still provide gradual lightening effects and improve overall skin tone