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In human NSCLC, conflicting results have been reported on the role of p53 mutations as a prognostic marker [109,110,111,112,113], likely due to the differing functional effects of specific p53 mutations

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The effects of acute citalopram dosing on gastric motor function and nutrient tolerance in healthy volunteers

These data support the calculation of the Maximum Recommended Starting Dose (MRSD) the starting dose for the first administration in humans, derived from preclinical data and converted to a human equivalent dose using internationally agreed methods