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Description
Diabetic rats have been observed to have reduced mitochondrial ATP production and elevated ROS levels (176)

The authors noted that poor or intermediate metabolizers demonstrate reduced drug clearance, which can elevate systemic exposure and increase ADR risk, whereas rapid or ultrarapid metabolizers may experience subtherapeutic exposure and treatment failure

PMC 4657456

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Deganutti G, Liang Y-L, Zhang X et al (2022) Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation
