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United States Reissued Patent USRE42645 (E) Drakulic T, Temple MD, Guido R, Jarolim S, Breitenbach M, Attfield PV, Dawes IW (2005) Involvement of oxidative stress response genes in redox homeostasis, the level of reactive oxygen species, and ageing in Saccharomyces cerevisiae

PGC-1 is known to regulate thermogenesis in BAT (Rao et al., 2014

With the liver preoccupied and under stress, its ability to efficiently produce IGF-1 and perform other crucial metabolic functions is severely impaired

MPs are immunogenic and induce the accumulation of TNF and other cytokines, such as IL-12, IL-6, IL-10, IFN-, and IL-8, in monocytes (Martinez and Casadevall, 2005

5 Pharmacological PRMT5/MAT2A inhibition and selectivity for MTAP-deficient cells A limiting factor to targeting PRMT5 directly is its important role in normal tissue function, but a synthetically lethal interaction with an MTAP -negative background should, in principle, provide a suitable therapeutic window

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