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For Groups 58, all was immunized with sheep red blood cells (5109/ml) intraperitoneally, where Group-5 was immunized control animals, Group-6 was immunized folate-deficient diet-fed animals, Group-7 was immunized control animals treated with aspartame orally for 90 days (40mg/kg.body weight/day), and Group-8 was immunized folate-deficient diet-fed animals treated with aspartame orally for 90 days (40mg/kg.body weight/day)