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La somministrazione cronica orale di alte dosi di levocarnitina in pazienti con grave compromissione della funzione renale o con insufficienza renale allo stadio terminale (ESRD) e dializzati pu indurre un accumulo dei metabolici potenzialmente tossici trimetilamina (TMA) e trimetilamina-N-ossido (TMAO), in quanto questi metaboliti vengono normalmente escreti con le urine

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Among other factors, in patients with ESRD, the presence of carnitine in serum and its quantity dictate the quality of response to rhEPO [62]

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We were unable to perform subgroup analyses, as there were inadequate trials that used similar comparisons
