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It also plays a role in cell division

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However, the pathomechanisms underlying the disease remain incompletely understood

IGF-1 is synthesized primarily in the liver and various peripheral tissues in response to growth hormone signalling and exerts its biological effects through binding to the IGF-1 receptor, a transmembrane tyrosine kinase receptor

Evidence indicates that chronic hypoxia directly damages testicular germ cells, reducing sperm count and compromising sperm DNA integrity, apoptosis, and autophagy
