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Results showed that the ingredient significantly increased NAD+ levels in senescent fibroblasts, activated the SIRT1 signaling pathway, reduced the expression of senescence-associated -galactosidase (SA--gal), decreased intracellular reactive oxygen species accumulation, and promoted collagen synthesis

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If they make an exception for one patient, they may feel pressured to do so for others, leading to a system where ad-hoc changes become the norm

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AOD-9604 is not FDA-approved for any indication, and all use represents off-label application requiring informed medical decision-making