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Hypophagia induced by salmon calcitonin, but not by amylin, is partially driven by malaise and is mediated by CGRP neurons

Inflammation and oxidative stress in sleep-deprived mice were measured by MCP-1 and nitrotyrosine staining, respectively, and quantitated by ImageJ digital analysis

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This is consistent with our prior immunohistochemical observations showing an increased density of CCK-positive excitatory neurons in the mPFC of KI animals

Avoid tirzepatide if you have a personal or family history of medullary thyroid carcinoma or MEN 2 (boxed warning), a history of pancreatitis, severe gastrointestinal motility disease, or known hypersensitivity to tirzepatide