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Emerging therapeutic opportunities of novel thiol-amides, NAC-amide (AD4/NACA) and thioredoxin mimetics (TXM-Peptides) for neurodegenerative-related disorders

Kocher, A

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ATP insufficiency also adversely affects neuronal function by disrupting Ca + regulation, impairing synaptic activity and neurotransmitter synthesis (7880)., and activating the AMPK-mTOR pathway to inhibit protein synthesis and cellular repair (81, 82)

At zinc doses higher than 50 mg/day, symptoms such as nausea, diarrhoea and abdominal discomfort may occur, whilst doses higher than 150 mg/day can adversely affect the bodys lipid profile and immune system

Gene Set Enrichment Analysis: A Knowledge-Based Approach for Interpreting Genome-Wide Expression Profiles