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doi:10.1038/nchembio.1204

Patients who typically benefit from vitamin B12 injections include individuals diagnosed with vitamin B12 deficiency, those experiencing difficulties absorbing nutrients through their digestive tract, or patients who follow restrictive dietary patterns, such as strict vegetarians or vegans

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Due to the emerging role of NAD homeostasis in aging and age-related diseases, our discovery of the role of CD38 in the control of cellular NAD levels opens the possibility that CD38 inhibition may be used as a therapeutic approach to increase cellular NAD levels (Figure 1)[1-4, 6]

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