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In some embodiments, the formulations or compositions described herein are liquids and are administered via narrow gauge needles or cannulas (e.g., 22 gauge needle, 25 gauge needle, or cannula), minimizing damage to the tympanic membrane upon administration

The lyophilized powder form can tolerate freezing because the water has already been removed

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This injection is commonly used in patients suffering from vitamin B deficiencies, neuropathic pain, neuritis, and general weakness

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Table 1 Condensed overview of the 101 evidence-based consensus statements and research priorities along with respective rating the quality-level of evidence (Quality Rating Scheme for Studies and Other Evidence, modified from Oxford Center for Evidence-Based Medicine: 1 = properly powered and conducted RCT/systematic review with meta-analysis