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Recombinant adeno-associated viruses have been harnessed as vehicles to deliver RNA interference (RNAi) therapies in preclinical HD models, showing some promise in slowing disease progression

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[2] The drug distributes widely, crosses the blood-brain barrier, and produces rapid onset of action-often within minutes after IV push-because high lipophilicity accelerates central nervous system penetration

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ASTRO 2002 Annual Meeting, 2002

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