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Onofrj et al., 2013

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Symptomatic treatment for PAD adds maximal risk factor modification, exercise, and, when indicated, invasive treatment using balloon angioplasty with or without stenting and bypass surgery together

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Commonly suggested biomedical hypotheses to explain PAIS (such as in long COVID/PASC, ME/CFS) are chronic stimulation of the immune system by a persistent infection or persistent unviable pathogen structures