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These include: Nausea, vomiting, and diarrhoea (very common, especially during dose escalation) Reduced appetite and abdominal discomfort Constipation Risk of hypoglycaemia when used with insulin or sulphonylureas Pancreatitis and gallbladder disease have been reported Thyroid C-cell tumours have been observed in animal studies, though the relevance to humans is unknown Important safety considerations when using both treatments include: Mounjaro can reduce the effectiveness of oral contraceptives due to delayed gastric emptying

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10.1089/ars.2012.4979 314 VaradharajS.KellyO

Thats exactly why Novo Nordisk combined cagrilintide with semaglutide in CagriSemathe idea is that hitting both the amylin and GLP-1 pathways together could produce greater effects than either one alone

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Both needed surgery