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Intramuscular delivery bypasses GI absorption entirely

The synovium that lines the knee joint capsule, producing synovial fluid to lubricate the joint and reduce friction, can become inflamed, thickening the capsule

After ingestion, stomach acid separates B12 from food proteins, and then intrinsic factor produced in the stomach lining binds to B12 so it can be absorbed in the ileum (the final section of the small intestine)

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