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318 , E237e248 (2020)

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doi: 10.1038/nn1791

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Several additional THR agonists are undergoing clinical evaluation, including ASC41 (phase II, China) (163, 164), HSK31679 (early study) (162), TERN-501 (165) (phase IIa), Sobetirome (GC-1, half before phase II) (164, 166), Eprotirome, Sobetirome, exhibited lipid-lowering effects in phase I trials under both single and multiple dosing regimens