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The authors suggest that the amount of Acetyl-CoA in the mitochondrion available for esterification of free carnitine was reduced in fasted or energy-restricted animals leading to increased tissue carnitine concentrations while acetylcarnitine levels were reduced [111]

In addition, another limitation is the observational nature of the study, which complicates causal interpretation of the results

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We also performed subgroup analysis based on the route of administration (RoA

Levocarnil [Sigma-Tau, Ivry-sur-Seine, France] and Carnitor [Sigma-Tau, Gaithersburg, MD, USA])