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Intrinsic resistance stems from the inherent biological characteristics of a bacterial species and is present before any exposure to drugs
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349 Similarly, mutations in valosin-containing protein (VCP), a multifunctional AAA-ATPase essential for extracting ubiquitinated proteins from cellular structures and directing them toward degradation, cause multisystem proteinopathies that include ALS, FTD, and inclusion body myopathy
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Nevertheless, loss of dopaminergic neurons in the VTA has also been observed in PD, although this loss is more evident in advanced stages of the disease
