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In two randomized, crossover studies, multiple daily doses of Depakote were compared to 8 to 20% higher once-daily doses of Depakote ER
Imaging versus Intervention in Managing Small Unruptured Intracranial Aneurysms: A Cost-Effectiveness Analysis
Zhang et al., 2019)
Not recommended for children, pregnant or breastfeeding women, or individuals sensitive to caffeine
This increase was accompanied by a significant shift in the balance between GABA and glutamate, with a relative 50% increase on the GABAergic side ( p = 0.025)
X., Yin J., Sheng H
