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Similarly, TFEB-mediated autophagy played a crucial role in the protective effects of UA in BV2 cells by upregulating the expressions of Beclin-1, LAMP1, and the LC3II/I ratio, while the knockdown of TFEB by siRNA markedly decreased autophagy activity in A + UA-treated BV2 cells
The liver is also exposed to gastrointestinal-derived pathogen-associated molecular patterns (PAMPs) due to the impact of ethanol on gut integrity
Cancer cells overexpressing xCT present an overactivation of the glucose-dependent PPP, as a mean of replacing NADPH consumed in the imperative conversion of cystine into cysteine (111) and by signaling pathways activated by oxidative stress, including PI3K/AKT/mTOR (112, 113) and MAPK pathways (110)
Shankar et al., 2025)
Through in-depth research in these areas, the therapeutic potential of DPP1 inhibitors can be fully explored, providing more precise and effective treatment regimens for patients
Habiba U, Ali S, Rizwan M et al (2019) Alleviative role of exogenously applied mannitol in maize cultivars differing in chromium stress tolerance
