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Evaluation of the efficacy and safety of deferiprone compared with deferasirox in paediatric patients with transfusion-dependent haemoglobinopathies (DEEP-2): a multicentre, randomised, open-label, non-inferiority, phase 3 trial

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Glutamate excitotoxicity causes Ca 2+ mediated NO production leading to mitochondrial dysfunction resulting in superoxide production, which is released via voltage dependent anion channels into the cytosol

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Cunningham-Rundles S, McNeeley DF, Moon A