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The medication works by enhancing insulin secretion in a glucose-dependent manner, suppressing glucagon release, and slowing gastric emptying, which collectively improves glycemic control and promotes weight loss

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This has contributed to a heated debate about the efficacy of treatments such as cognitive behavioural therapy (CBT) and graded exercise therapy (GET), used primarily in the PACE trial [149], for those meeting stricter criteria for ME/CFS, such as the Canadian Consensus Criteria or the International Consensus Criteria

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