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Sometimes it is too much

Contact your GP or healthcare professional if you experience: Persistent vomiting lasting more than 2448 hours, particularly if you cannot keep down fluids Signs of dehydration including dark urine, dizziness, dry mouth, reduced urination, or feeling faint when standing Abdominal pain , especially if severe, constant or located in the upper abdomen radiating to the back Visual changes in vomit, such as blood (appearing red or resembling coffee grounds) Inability to take other essential medications due to vomiting Significant weight loss beyond expected therapeutic effects Symptoms of gallbladder disease including pain in the upper right abdomen, fever, or yellowing of the skin/eyes Symptoms of bowel obstruction such as abdominal distension, inability to pass stool or gas If your GP is unavailable, contact NHS 111 for advice

Women requiring reliable contraception while on tirzepatide therapy should discuss contraceptive options with their prescribing provider

Symptoms of tirzepatide overdose include severe nausea within 2-4 hours, vomiting that may persist 12-24 hours, diarrhea, abdominal cramping, dehydration, and in some cases, hypoglycemia if combined with other diabetes medications

The distribution is highly skewed: a straightforward rare disease drug with a defined biomarker, approved via accelerated approval on 150 patients, may cost USD 150-300 million to develop

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