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References 1.Ludwig J, Hashimoto E, McGill DB, van Heerden JA

The VDAC family located in the outer mitochondrial membrane acts as a gatekeeper for the entry and exit of mitochondrial metabolites, thereby controlling the crosstalk between the mitochondria and the rest of the cell during oxidative stress

Increased mitochondrial membrane permeability leads to the release of cytochrome c (Cyt c) from the mitochondria into the cytoplasm