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Tirzepatide: Dual GIP/GLP-1 Receptor Agonist Tirzepatide activates two receptor types simultaneously: GLP-1: Same appetite suppression and insulin-stimulating benefits as semaglutide GIP (Glucose-dependent insulinotropic polypeptide): Improves insulin sensitivity, influences fat metabolism, and may change how the body responds to nutrient intake GIP receptor activation is what sets tirzepatide apart

The energy benefit is modest

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DOI: 10.1038/s41591-023-02597-w [17] Aronne, L.J., Sattar, N., Horn, D.B., et al

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While caution is still recommended, emerging evidence suggests that the risks may be lower than previously thought