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Most of these clogs would eventually make their way to the surface as open comedones (blackheads) or closed comedones (whiteheads), both known as non-inflammatory acne

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doi: 10.1210/jc.2004-0785 129 GiulianiCBucciIDi SantoSRossiCGrassadoniaAPiantelliMet al

in- hibits production of neurotransmitters by inhibiting: cal- cium-dependent neurotransmitter release [10], dihydro- teridine reductase [14], nitric oxide synthase [15], block- ing neurotransmitter amino acids [16], causes abnormal migration of neurons in the cerebral cortex [17] and hence continues to pose appreciable risk to human health as evidenced by the tragic epidemics of mercury poison- ing in Japan and Iraq [18]

Thus, an improved understanding of the regulation of UA and its neuroprotective action in the human brain will shed further light on neurodegenerative processes and potentially identify novel targets for pharmacotherapeutic intervention