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The key role of histone acetylation in mGlu2 receptor regulation is also strengthened by the findings that chronic treatment with atypical antipsychotics down-regulates the expression of mGlu2 receptors in the mouse and human prefrontal cortex by increasing the binding of HDAC2 to the Grm2 promoter [39]

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SMD 0.28, 95% CI 0.77 to 0.20), with evidence of a between-group difference (p=0.03)

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